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Examples
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Azacitidine, for example, was first discovered in Czechoslovakia in the 1960s as a traditional chemotherapy drug, and doctors used it to kill cancer cells the old-fashioned way: giving as much as patients could tolerate.
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Azacitidine is used to treat patients with myelodysplastic syndromes
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Azacitidine is an epigenetic compound believed to exert antineoplastic effects by causing hypomethylation of DNA and direct cytotoxicity on abnormal hematopoietic cells in the bone marrow.
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Azacitidine was also the first drug approved by the FDA for the treatment of all five French, American, British (FAB) MDS subtypes which includes both low-risk and high-risk patients.
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Azacitidine has received orphan drug designation in the U.S. and European Union.
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- Azacitidine is contraindicated in patients with a known hypersensitivity to azacitidine or mannitol and in patients with advanced malignant hepatic tumors.
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- Azacitidine may cause fetal harm when administered to a pregnant woman.
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Advance Development Program of Oral Azacitidine in Solid Tumors
unknown title 2011
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Phase I Study of Oral Azacitidine in Myelodysplastic Syndromes, Chronic Myelomonocytic Leukemia, and Acute Myeloid Leukemia Published in
unknown title 2011
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MGCD265, in Solid Tumor Cancers Clinical Data on Vidaza (R) (Azacitidine for Injectable Suspension) in Various Hematologic and Solid Tumor Cancers Presented at the American Society of Clinical Oncology 42nd Annual Meeting ZIOPHARM Announces Interim Results in ZIO-101 Phase I Solid Tumor Cancer Trial; Clinical Activity in Several Cancers Mice Put Cancer on Ice?
unknown title 2009
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