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Examples
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Smith's work forms the basis for site-directed mutagenesis, a technique by which it is possible to change a specific amino-acid in a protein and thereby illuminate its functional role.
The Nobel Prize in Chemistry: The Development of Modern Chemistry 2010
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Sanger of Cambridge, and he reported the amino-acid sequence for a protein, insulin, in 1955.
The Nobel Prize in Chemistry: The Development of Modern Chemistry 2010
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Svedberg's investigations with the ultracentrifuge and Tiselius's electrophoresis studies (see Section 3.10) were instrumental in establishing that protein molecules have a unique size and structure, and this was a prerequisite for Sanger's determination of their amino-acid sequence and the crystallographic work of
The Nobel Prize in Chemistry: The Development of Modern Chemistry 2010
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Though our cells have no trouble following instructions for building the protein, predicting that shape from the amino-acid sequence is fiendishly hard for our minds, even assisted by computers.
Following the Crowd to Citizen Science Matt Ridley 2012
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Moore and Stein had determined the amino-acid sequence of ribonuclease, but they received the prize for discovering anomalous properties of functional groups in the enzyme's active site, which is a result of the protein fold.
The Nobel Prize in Chemistry: The Development of Modern Chemistry 2010
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Getty Images A newborn baby's feet Some states have expanded their checks, including testing for amino-acid and metabolism disorders.
New Tests for Newborns, And Dilemmas for Parents Amy Dockser Marcus 2011
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Anfinsen had shown, with the enzyme ribonuclease, that the information for a protein assuming a specific three-dimensional structure is inherent in its amino-acid sequence, and this discovery was the starting point for studies of the mechanism of protein folding, one of the major areas of present-day biochemical research.
The Nobel Prize in Chemistry: The Development of Modern Chemistry 2010
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The amino-acid sequence of a protein, determined by a gene, in turn determines the shape of the protein.
Following the Crowd to Citizen Science Matt Ridley 2012
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There are a huge number of possible amino-acid combinations.
SO STRESSED William Kent Krueger 2010
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There are a huge number of possible amino-acid combinations.
SO STRESSED William Kent Krueger 2010
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