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Examples
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The V-region of Ak-1 contains unique structures which stimulate the production of various anti-antibodies (Ak-2).
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Experimental autoimmune disease has been successfully treated with anti-antibodies.
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The production of anti-pollen antibodies has been prevented in animals by anti-antibodies.
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Moreover, anti-antibodies can stimulate the production of still another generation of antibodies, anti-anti-antibodies.
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Each antibody generation induces the production of still another and larger set of anti-antibodies in a cascade-like manner.
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A basis for the network theory was the observation that antibodies can elicit anti-antibodies directed against antigen binding structures on the first antibody (Figure
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