Definitions
from The American Heritage® Dictionary of the English Language, 5th Edition.
- noun Any of various enzymes that are produced by certain bacteria, including most strains of staphylococci, and that hydrolyze and inactivate penicillin.
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun biochemistry An
enzyme produced by certainbacteria , responsible for theirresistance tobeta-lactam antibiotics such aspenicillin .
from WordNet 3.0 Copyright 2006 by Princeton University. All rights reserved.
- noun enzyme produced by certain bacteria that inactivates penicillin and results in resistance to that antibiotic
Etymologies
from The American Heritage® Dictionary of the English Language, 4th Edition
from Wiktionary, Creative Commons Attribution/Share-Alike License
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Examples
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For example, in my early college research, I worked on means of overcoming penicillin beta-lactamase mechanisms of penicillin resistance.
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Antibiotics such as penicillin are called, collectively, beta-lactams, and enzymes that break down these antibiotics and confer drug resistance are called beta-lactamases, which is why the term beta-lactamase may pop up in this blog entry from time to time.
Axe (2004) and the evolution of enzyme function - The Panda's Thumb 2007
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This is found to cause complete loss of function in vivo for two unrelated monomeric enzymes: barnase a bacterial RNase and TEM-1 beta-lactamase.
"Intro to ID" by Gonzalez at U of Northern Iowa - The Panda's Thumb 2005
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Using these simplifications, the difficulty of specifying a working beta-lactamase domain is assessed here.
"Intro to ID" by Gonzalez at U of Northern Iowa - The Panda's Thumb 2005
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NXL 104 is the last, the boldest beta-lactamase inhibitor now in development in clinical trials.
Forest Laboratories Q3 2011 Earnings Call Transcript - Seeking Alpha 2011
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NXL 104 is a compound that inhibits several classes of bacterial enzymes called beta-lactamase that break down and activate beta-lactam antibiotics such as: Cephalosporin, a class to which ceftaroline belongs; penicillins; and carbapenems, making the pathogens producing these enzymes resistant to these antibiotics.
Forest Laboratories Q3 2011 Earnings Call Transcript - Seeking Alpha 2011
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It overcomes bacterial resistance by several mechanisms and is not easily destroyed by bacterial beta-lactamase enzymes, such as extended-spectrum beta-lactamases (ESBLs), carbapenemases and the recently characterized New Delhi metallo-beta-lactamase 1 (NDM-1), which cause resistance against many currently marketed antibiotics.
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K. pneumoniae, including extended-spectrum beta-lactamase (ESBL) and multidrug-resistant (MDR) strains.
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Forest licensed Novexel, a French biotech company, the rights for North America for NXL 104, a beta-lactamase inhibitor for use in combination with ceftaroline.
Forest Laboratories Q3 2011 Earnings Call Transcript - Seeking Alpha 2011
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Chronically, no other beta-lactamase inhibitor available on the market can do better.
Forest Laboratories Q3 2011 Earnings Call Transcript - Seeking Alpha 2011
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