cohesin

Our findings point to cohesin being a major culprit in this.

BBC News - Home 2010

The researchers looked at eggs from young and old mice - and found cohesin levels declined with age.

BBC News - Home 2010

By tracking chromosomes during division in the egg, the Newcastle team found that the reduced cohesin in eggs from older females resulted in some chromosomes becoming trapped and unable to divide properly.

BBC News - Home 2010

"If we can understand this, we will be in a better position to know if there is any possibility of developing interventions to help reduce cohesin loss."

BBC News - Home 2010

She said the next step was to look at human egg development, and work out why cohesin is lost with age.

BBC News - Home 2010

If there is too little cohesin, the structure can be too "floppy" for division to happen equally.

BBC News - Home 2010

Bardhan A, Chuong H, Dawson DS (2010) Meiotic cohesin promotes pairing of non-homologous centromeres in early meiotic prophase.

PLoS ONE Alerts: New Articles David Obeso et al. 2010

"Mediator and cohesin connect gene expression and chromatin architecture"

Newswise: Latest News 2010

Bardhan A, Chuong H, Dawson DS (2010) Meiotic cohesin promotes pairing of non-homologous centromeres in early meiotic prophase.

PLoS ONE Alerts: New Articles David Obeso et al. 2010

Writing in Current Biology, they said understanding this process could help develop ways to prevent cohesin loss.

BBC News - Home 2010

One of her fundamental discoveries is that cohesin (a protein that acts like a “molecular glue” holding chromosomes together until the right time and place) disintegrates with age.

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