detrusor

Detrol is a drug that is FDA-approved for treatment of overactive bladder (we docs like to call it detrusor instability).

Take Your Bladder Back from Pfizer aka TBTAM 2008

For, in fact, neither the bladder nor rectum ever acts voluntarily per se any more than the stomach does, and therefore the name "detrusor" urinae, as applied to the muscular coat investing the bladder, is as much a misnomer (if it be meant that the act of voiding the organ at will be dependent upon it) as would be the name "detrusor" applied to the muscular coat of the stomach, under the meaning that this were the agent in the spasmodic effort of vomiting.

Surgical Anatomy Joseph Maclise

Austin JC, Chacko SK, DiSanto M, Canning DA, Zderic SA: A male murine model of partial bladder outlet obstruction reveals changes in detrusor morphology, contractility and myosin isoform expression.

Publications of the Urology Division 2010

Other health implications of urinary incontinence in people living with MS or spinal cord injury include skin irritation and ulcers, kidney failure 4,11 and recurrent urinary tract infections, which may lead to serious health consequences, if the overactivity of the detrusor muscle is not treated.

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InvestiGation of purified Neurotoxin complex In neurogenic deTrusor overactivitY was Allergan's phase III clinical programme evaluating the safety and efficacy of BOTOX® as a treatment in patients suffering from urinary incontinence due to neurogenic detrusor overactivity.

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So I think whether we have the idiopathic trial going or not, will not change what the FDA does for neurogenic detrusor overactivity license.

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The French Regulatory Agency, AFSSAPS, made France the first country to -- European country to issue a Positive Opinion for BOTOX for urinary incontinence associated with neurogenic detrusor overactivity with a license to be issued in due course.

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Urinary incontinence in patients with MS or SCI is frequently caused by a condition called neurogenic detrusor overactivity NDO, which results in involuntary contractions of the bladder during the filling stage when the bladder should be relaxed.

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Clearly, the next catalyst for this franchise is the anticipated FDA and the European approval to BOTOX for incontinence due to detrusor overactivity associated with the neurological condition.

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Patients were randomised to receive a physician-administered single treatment of placebo, 200 or 300 Units of BOTOX® injected as one procedure into the detrusor muscle using a rigid or flexible cystoscope.

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