Definitions
from The American Heritage® Dictionary of the English Language, 5th Edition.
- noun A potent, naturally occurring antiangiogenic protein that inhibits the formation of the blood vessels that feed tumors. It is under investigation as a potential cancer therapy.
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun biochemistry A
protein which inhibits the formation of theblood vessels that supplytumours .
Etymologies
from The American Heritage® Dictionary of the English Language, 4th Edition
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Examples
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We have also shown that anti-angiogenic factors, such as endostatin, counteract proangiogenic effects in the eye (
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We have also shown that anti-angiogenic factors, such as endostatin, counteract proangiogenic effects in the eye (
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Even people like Duane Gay, one of the first humans to be treated with endostatin, knows that the drug may not save him.
Folkman Looks Ahead 2007
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At least 20 drugs called angiogenesis inhibitors are now in clinical trials, including angiostatin and endostatin, the compounds isolated by Dr. Michael O'Reilly in Folkman's lab.
Folkman Looks Ahead 2007
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And sophisticated imaging showed that as doses of endostatin increased, blood flow to tumors decreased in some patients -- the goal of angiogenesis inhibitors.
Folkman Looks Ahead 2007
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But endostatin, under study at the Dana-Farber Cancer Institute in Boston, the M.D.
Folkman Looks Ahead 2007
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Simcere declares itself a maker of branded generic drugs, though it also makes the innovative cancer treatment Endu, a recombinant human endostatin and the stroke treatment edaravone.
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Simcere declares itself a maker of branded generic drugs, though it also makes the innovative cancer treatment Endu, a recombinant human endostatin and the stroke treatment edaravone.
China Stocks News and Analysis from Seeking Alpha ChinaBio Today 2010
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Structural analysis of the NC1 domain of collagen XVIII suggests that it consists of three segments, an N-terminal trimerization domain implicated in self-assembly of homotrimers; a central protease-sensitive hinge region; and the compact C-terminal endostatin domain
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The popularity of the idea waned in the early 2000s following disappointing results in clinical trials of two anti-angiogenic compounds, angiostatin and endostatin, that were discovered in Folkman's lab.
Latest Articles 2009
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