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Examples
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Both Erbitux and Vectibix target what scientists call epidermal growth-factor receptors, or EGFRs, which sit on the surface of cells.
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Now the company is searching for a growth-factor gene that would stimulate hair growth.
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One monoclonal antibody, called 1121B, works similarly to Genentech Inc. 's highly successful Avastin by inhibiting nutrient flow to tumors, and the other, A12, targets a growth-factor receptor.
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After completing graduate work at Wisconsin I was fortunate in being able to spend a year studying at the University of Utrecht with F. Kögl, the discoverer of the growth-factor biotin, and to work in the same laboratory with Nils Fries, who already had contributed significantly in the field of nutrition and growth of fungi.
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Having thus successfully tested with Neurospora the basic premise that the biochemical processes concerned with the synthesis of essential cell constituents are gene controlled, and alterable as a consequence of gene mutation, it then seemed a desirable and natural step to carry this approach to the bacteria, in which so many and various naturally occurring growth-factor requirements were known, to see if analogous nutritional deficiencies followed their exposure to radiation.
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Tarceva homes in on a specific area, or domain, of a very common cell-membrane receptor called EGFR, the epidermal growth-factor receptor.
PhysOrg.com - latest science and technology news stories 2010
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Tarceva homes in on a specific area, or domain, of a very common cell-membrane receptor called EGFR, the epidermal growth-factor receptor.
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(V617F) in the Janus kinase 2 (JAK2) gene has been recently associated with key signaling abnormalities in the transduction of haemopoietic growth-factor receptors and is now considered as a useful clinical marker of myeloproliferative neoplasms.
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Inflammation-induced impairment of growth-factor mediated insulin sensitivity may be involved in the development of CIM.
BioMed Central - Latest articles Steffen Weber-Carstens 2010
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Next, we evaluated whether any differences existed between control cells and bcl-2 overexpressing clones in terms of HIF-1α induction in response to growth-factor stimulation, another condition that induces hypoxia-independent HIF-1α expression even in normoxia
PLoS ONE Alerts: New Articles Daniela Trisciuoglio et al. 2010
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