hyperinsulinism

The most common form of hyperinsulinism is caused by a defect in the potassium channel (KATP channel).

Diazoxide 2010

The second most common cause of hyperinsulinism is the hyperinsulinism/hyperammonemia syndrome, in which the gene defect has nothing to do with the potassium channel, but instead interferes with the metabolism of glutamate in the cell, causing excessive insulin secretion.

Diazoxide 2010

Congenital hyperinsulinism is rare; most children's hospitals encounter only one or two cases a year.

Congenital Hyperinsulinism Center 2010

The third type of hyperinsulinism, which is extremely rare, is glucokinase hyperinsulinism.

Diazoxide 2010

The Hyperinsulinism Center specializes in the diagnosis and treatment of children with hyperinsulinism, also called persistent hyperinsulinemic hypoglycemia of infancy (PHHI), a disorder that causes low blood sugar (hypoglycemia).

Endocrinology 2010

Remember, there are different types of hyperinsulinism, so your child's experience may be different from other children's.

Resources for Professionals 2010

GHD HI - Also referred to as hyperinsulinism-hyperammonemia syndrome or HI-HA.

What is HI? 2010

His diagnosis of hyperinsulinism was made based on three factors:

Nathaniel's focal disease was treated surgically at CHOP 2010

Thornton PS, Satin-Smith MS, Herold K, Glaser B, Chiu KC, Nestorowicz A, et al. Familial hyperinsulinism with apparent autosomal dominant inheritance: clinical and genetic differences from the autosomal recessive variant. [see comments].

Resources for Professionals 2010

Please see the following sections for information about congenital hyperinsulinism:

Diffuse KATP HI, SUR1, PHHI, Focal KATP HI, GDH HI, GK HI, SCHAD HI 2010