hypophysectomized

There is good utilization of carbohydrate in hypophysectomized animals.

Bernardo Houssay - Nobel Lecture 1964

Reciprocally in hypophysectomized animals there is hypersensitiveness to insulin, and in fasting, their blood sugar and glycogen falls more rapidly and markedly than in normal animals.

Bernardo Houssay - Nobel Lecture 1964

Ketonuria is also below normal in hypophysectomized animals in basal conditions and in the diabetic state, whatever its origin, therefore the consumption of fat also seems to be reduced.

Bernardo Houssay - Nobel Lecture 1964

Thus, even in these "hypophysectomized" rats we believe that residual pituitary fragments are the source of the brain ACTH (57).

Nobel Lecture Radioimmunoassay: A Probe For Fine Structure Of Biologic Systems 1977

The presence of pituitary hormones in the brains of commercially prepared hypophysectomized rats has been taken as evidence for de novo synthesis of pituitary hormones in the brain (54-56), (58).

Nobel Lecture Radioimmunoassay: A Probe For Fine Structure Of Biologic Systems 1977

Nonetheless although there is an immediate decrease in stress-stimulated ACTH release in hypophysectomized rats, after two months the plasma ACTH concentrations can be stress-stimulated to about 80% of the level found in intact rats

Nobel Lecture Radioimmunoassay: A Probe For Fine Structure Of Biologic Systems 1977

Nevertheless, this important discovery does not explain all the facts, e.g. the hypersensitiveness to insulin of hypophysectomized animals.

Bernardo Houssay - Nobel Lecture 1964

It can not be obtained in the hypophysectomized pancreatectomized toad if the liver has been removed.

Bernardo Houssay - Nobel Lecture 1964

Hepatic and muscular glycogen falls rapidly in fasting hypophysectomized animals.

Bernardo Houssay - Nobel Lecture 1964

Extrapancreatic: factors are demonstrated by: (1) the diabetogenic effect obtained in pancreatectomized hypophysectomized animals; (2) the increase in the severity of diabetes in pancreatectomized dogs treated with anterohypophyseal extract; (3) the increase in resistance to insulin which precedes and accompanies hypophyseal diabetes; (4) the fact that hyperglycemia and diabetes occur before that there are visible lesions in the beta cells of the islets, and before insulin secretion diminishes.

Bernardo Houssay - Nobel Lecture 1964