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  • Discovered in 1957 by a Swiss pharmaceutical firm, isotonitazene is an analogue of its banned parent compound, etonitazene, which was discovered in 1956 and is itself 60 times more potent than morphine.

    “Isotonitazene is the most persistent and prevalent new opioid in the U.S.,” said Logan, adding that he is now seeing 40 to 50 isotonitazene-related deaths per month in the U.S. compared to about six per month last summer (2019).


    Isotonitazene is legal to export from China and is not specifically banned in the U.S., Europe or China. America’s Analog Act would cover it as a derivative of a banned substance, but no case has come to court yet. It could take years before it is scheduled in the U.S. and internationally.

    Chemists in Shanghai and other major manufacturing centers are still out-inventing lawmakers the world over, quickly synthesizing new, legal variants of recently banned drugs. Isotonitazene and several variants of it are now being sold online, legally by Chinese suppliers offering bulk deals.

    July 30, 2020