Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License.

  • verb biochemistry (of a protein or nucleic acid) To fold into an unusual or incorrect tertiary structure; often a cause of Alzheimer's and similar diseases

Etymologies

Sorry, no etymologies found.

Support

Help support Wordnik (and make this page ad-free) by adopting the word misfold.

Examples

  • The second study, conducted by an international team of researchers, describes a genetically-linked "misfold" in neural protein as a possible cause of autism.

    About.com Autism 2010

  • Moreover, when proteins do not fold correctly (i.e. "misfold"), there can be serious consequences, including many well known diseases, such as Alzheimer's, Mad Cow (BSE), CJD,

    Southern Maryland Community Forums Boogieman117 2010

  • It's believed when they "misfold" it results in physical problems such as Alzheimer's disease, cystic fibrosis, and some cancers.

    Computer And Video Games 2009

  • If they misfold, the flaws can cause serious health problems, such as Alzheimer's disease or cancer.

    Gene Expression: Origami at the Molecular Level 2009

  • I am not sure if one prion strain can spontaneously “mutate” into another, although that might perhaps be possible at some low rate, just like a normal protein can on occasion misfold spontaneously into a prion.

    More prion news - The Panda's Thumb 2006

  • I am not sure if one prion strain can spontaneously “mutate” into another, although that might perhaps be possible at some low rate, just like a normal protein can on occasion misfold spontaneously into a prion. jr

    More prion news - The Panda's Thumb 2006

  • "When proteins misfold, they sometimes clump together, forming aggregates in the brain that have been observed in patients with Alzheimer's, Parkinson's and other diseases."

    Boing Boing: October 20, 2002 - October 26, 2002 Archives 2002

  • What makes this housekeeping protein spontaneously misfold and accumulate in cases of noninherited A.L.S.?

    NYT > Home Page By AMANDA SCHAFFER 2011

  • What makes this housekeeping protein spontaneously misfold and accumulate in cases of noninherited A.L.S.?

    NYT > Home Page By AMANDA SCHAFFER 2011

  • Aggregation-prone proteins often misfold into multiple distinct amyloid conformations that dictate different physiological impacts.

    Naturejobs - All Jobs Yumiko Ohhashi 2010

Comments

Log in or sign up to get involved in the conversation. It's quick and easy.