Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun Plural form of
morpholino .
Etymologies
Sorry, no etymologies found.
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Examples
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The patches, DNA-like molecules called morpholinos, are manufactured in a laboratory.
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To determine the function of the two novel proteins, the team knocked down their genes, and1 and and2, using morpholinos, molecules that silence gene expression.
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The study was limited to only a few days by the short lifespan of the RNA-blocking morpholinos, so it was not possible for Akimenko to determine whether disrupting the and genes also prevents the formation of other parts of the fin skeleton that disappeared during the fin-to-limb transition.
Scientific American 2010
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The study was limited to only a few days by the short lifespan of the RNA-blocking morpholinos, so it was not possible for Akimenko to determine whether disrupting the and genes also prevents the formation of other parts of the fin skeleton that disappeared during the fin-to-limb transition.
Scientific American 2010
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The researchers theorized that the muscles of the heart are less porous than the skeletal muscles, and did not absorb sufficient quantities of the morpholinos to curb the deterioration.
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Eaf2/U19 (Eafs) - morpholinos increased the severity of defects, suggesting that Eaf1 and Eaf2/U19 only share some functional redundancy.
Journal of Biological Chemistry current issue Liu, J.-X., Hu, B., Wang, Y., Gui, J.-F., Xiao, W. 2009
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The researchers said that other means of delivering the morpholinos to the heart would need to be explored.
WANE TV 2009
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Successful systemic treatment with morpholinos requires large doses of the antisense molecules-and the technology is costly and difficult to obtain.
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They added, however, that the study results showed that it would be possible to use a cocktail of morpholinos to patch the multiple mutations that occur in the human form of the disorder.
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The Salk researchers depleted FoxJ1 in both Xenopus and zebrafish by injecting embryos with morpholinos, synthetic DNA-like structures that bind to nucleic acids and work like dimmer switches to turn down gene expression.
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