muscarinic

The accidental finding was that on the preparation of rabbit aorta being used in the experiment, the muscarinic agents acetylcholine and carbachol induced relaxation rather than the expected contraction.

Robert F. Furchgott - Autobiography 1999

He first pharmacologically characterized with the use of various muscarinic agonists and antagonists the prejunctional receptor through which acetylcholine produces a marked inhibition of norepinephrine release (monitored by both the degree of vasoconstriction and [3H] norepinephrine release).

Robert F. Furchgott - Autobiography 1999

(Bursztyn) Goldberg (a graduate student) and I compared the dissociation constants and relative efficacies of agonists acting on muscarinic cholinergic receptors of isolated strips of rabbit stomach fundus muscle; and later John Besse (a postdoctoral fellow) and I compared the dissociation constants and relative efficacies of agonists acting on 1-adrenergic receptors of rabbit aorta.

Robert F. Furchgott - Autobiography 1999

GSK961081 is a single molecule functioning as both a muscarinic antagonist and a beta2 receptor agonist

unknown title 2011

We believe that aclidinium, a proprietary long-acting inhaled muscarinic antagonist, and formoterol, a long-acting inhaled beta agonist may be a desired combination for the treatment of COPD

Almirall and Forest Announce Positive Results from the ATTAIN Phase III Study of Aclidinium Bromide and the Phase IIb Studies with the Fixed Dose Combination with Formoterol in Moderate to Severe COPD Patients - Yahoo! Finance 2011

TD-4208, an inhaled muscarinic acetylcholine receptor AChR antagonist, for the potential treatment of chronic obstructive pulmonary disease COPD; think Spiriva from PFE/BI.

unknown title 2011

We believe that aclidinium, a proprietary long-acting inhaled muscarinic antagonist, and formoterol, a long-acting inhaled beta agonist may be a desired combination for the treatment of COPD

Almirall and Forest Announce Positive Results from the ATTAIN Phase III Study of Aclidinium Bromide and the Phase IIb Studies with the Fixed Dose Combination with Formoterol in Moderate to Severe COPD Patients - Yahoo! Finance 2011

ANAVEX 2-73 is the first of a new class of compounds that act through sigma-1 receptor agonism as well as muscarinic cholinergic effects and modulation of endoplasmic reticulum stress thought to trigger a series of intracellular effects which modify ion channel signaling at the mitochondrial level.

Alzheimer's Weekly names ANAVEX 2-73 the number one most promising trial drug in Alzheimer's disease and Anavex's Phase I clinical program as "Trial of the Year" - Yahoo! Finance 2011

Cariprazine also has a relatively low potency at other receptor sites, such as 5-HT2C, histamine H1, and muscarinic and adrenergic receptor sites which have been associated with adverse events.

unknown title 2011

-- A selective allosteric potentiator of the M1 muscarinic acetylcholine receptor increases activity of medial prefrontal cortical neurons and restores impairments in reversal learning.

PhysOrg.com - latest science and technology news stories 2010