Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun biochemistry Any of a family of
proteins that areRNA -binding factors - noun genetics Any of the
genes associated with these proteins
Etymologies
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Examples
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One is called muscleblind-like, "which is sopped up by the RNA repeats, causing problems," said Cooper.
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In this study scientists from the University of Rochester in New York found the blocking of a protein called "muscleblind" causes the characteristic hand stiffness.
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"muscleblind," thought to be a key factor in myotonic dystrophy.
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Most prominently, the transcribed CTG and CCTG repeats both bind muscleblind-like (MBNL) and CUGBP1/ETR-3-like factors (CELF) that are involved in alternative RNA splicing.
PLoS ONE Alerts: New Articles Morgan A. Sammons et al. 2010
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Urbinati CR, Teng-Umnuay P, Stenberg MG, Byrne BJ, et al. (2000) Recruitment of human muscleblind proteins to (CUG) (n) expansions associated with myotonic dystrophy.
PLoS ONE Alerts: New Articles Anna Matynia et al. 2010
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Kanadia RN, Johnstone KA, Mankodi A, Lungu C, Thornton CA, et al. (2003) A muscleblind knockout model for myotonic dystrophy.
PLoS ONE Alerts: New Articles Anna Matynia et al. 2010
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Other researchers are looking at molecules that can prevent muscleblind-like protein from binding RNA in the nucleus.
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"In theory, if you could make that happen might you might actually make this disease go in reverse." molecule, succeeded in pulling apart the RNA and the muscleblind proteins.
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To test whether CUGexp RNA creates a global splicing defect, we compared the skeletal muscle of two mouse models of DM1, one expressing a CTG exp transgene and another homozygous for a defective muscleblind 1 (
Naturejobs - All Jobs Hongqing Du 2010
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