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Examples
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So I asked hrun what functions these post-synaptic genes serve in sponges. [hrun] didn't respond, so I went looking to see if Mike's FLE 'expectation' that these genes are expressed and perform a function in sponges that was selected for and allowed these genes to persist could be supported.
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I went through the entire paper and couldn't find a single mention of any "mysterious unknown structure" in sponges, nor any assertions that this mystery structure is an expression these post-synaptic genes.
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A relatively small number of crucial innovations to this pre-existing structure may represent the founding changes that led to a post-synaptic element.
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After the neurotransmitter diffuses across the synaptic cleft it complexes with a receptor (membrane-bound macromolecule) on the post-synaptic side.
Neurotoxicity 2008
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This binding causes an ion channel to open, changing the membrane potential of the post-synaptic neuron or muscle or gland.
Neurotoxicity 2008
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This permits modelers to control and manipulate a variety of subcellular factors that determine action potentials per time unit (including the topology of membrane structure in individual neurons, variations in ion channels across membrane patches, field properties of post-synaptic potentials depending on the location of the synapse on the dendrite or soma).
The Philosophy of Neuroscience Bickle, John 2006
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In this study, we describe phenotypic responses that underscore the importance of the balance between the opposing activities of kinases and phosphatases at the post-synaptic terminals.
PLoS ONE Alerts: New Articles Michael Weisenhaus et al. 2010
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The serotonin is taken in by the receiving, post-synaptic cell, or be taken back by the pre-synaptic cell.
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To treat the depression, SSRIs decrease the ability of the pre-synaptic cell to reuptake the serotonin, leaving the message in the synapse longer and giving the post-synaptic cell a better chance of receiving the serotonin.
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What are the affinities for dopamine, serotonin and norepinephrine signalling components such as pre - and post-synaptic receptors and transporter mechanisms?
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