Definitions
from The Century Dictionary.
- noun A flesh-colored or yellow crystalline dyestuff, (C11H10O3)3 obtained from
Echinus Philippinensis . It is the active constituent of the vermifuge kamila. Also calledmallotoxin .
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun biochemistry An
protein kinase inhibitor derived from thekamala tree (Mallotus philippinensis)
Etymologies
Sorry, no etymologies found.
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Examples
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Anderson noted that a concentrated ethereal solution of kamala after a few days formed a solid crystalline mass, yellow, very soluble in ether; this substance he named _rottlerin_, C_11_H_10_O_3_.
The Medicinal Plants of the Philippines Jerome Beers Thomas 1891
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After stimulation with Wnt5a (1 μg/ml, 30 minutes, 1 hour, 2 hours), Gö 6976 (100 nM, 30 minutes), and/or rottlerin (1 μM), EPC was lysed with lysis buffer (Cell Signaling) containing
PLoS ONE Alerts: New Articles Masamichi Koyanagi et al. 2009
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Wnt5a (1 μg/ml) or PKC delta inhibitor, rottlerin (1 μM) were used. * indicates p doi: 10.1371/journal. pone.0005765.g003
PLoS ONE Alerts: New Articles Masamichi Koyanagi et al. 2009
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Importantly, increased cardiac marker gene expression by Wnt5a was also inhibited by rottlerin, suggesting that PKC delta is an important mediator for cardiac gene expression via non-canonical Wnt signaling.
PLoS ONE Alerts: New Articles Masamichi Koyanagi et al. 2009
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For the inhibitory assay, rottlerin (1 μM, Calbiochem), PKC epsilon translocation inhibitor peptide and its control peptide (both 25 μM, Calbiochem), or Gö6976
PLoS ONE Alerts: New Articles Masamichi Koyanagi et al. 2009
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The PKC delta inhibitor rottlerin significantly blocked co-culture-induced cardiac differentiation in vitro, whereas inhibitors directed against the classical Ca
PLoS ONE Alerts: New Articles Masamichi Koyanagi et al. 2009
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Incubation with the relatively selective PKC delta inhibitor, rottlerin (1 μM), significantly attenuated cardiac differentiation (
PLoS ONE Alerts: New Articles Masamichi Koyanagi et al. 2009
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