Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun An
anticonvulsant thatinhibits thecatabolism ofGABA by irreversiblyinhibiting GABAtransaminase .
Etymologies
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Examples
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Catalyst is also developing CPP-115, another GABA aminotransferase inhibitor that is more potent than vigabatrin and has reduced side effects e.g., visual field defects, or VFDs from those associated with vigabatrin.
unknown title 2011
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Catalyst has two products in development, and is currently evaluating its lead product and first-in-class GABA aminotransferase inhibitor candidate, CPP-109 vigabatrin, for the treatment of cocaine addiction.
unknown title 2011
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Catalyst is also developing CPP-115, another GABA aminotransferase inhibitor that is more potent than vigabatrin and has reduced side effects e.g., visual field defects, or VFDs from those associated with vigabatrin.
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The presentation discussed the medical relevance of GABA aminotransferase inactivators in the treatment of epilepsy and drug addiction, the history of the discovery of CPP-115, a detailed mechanistic analysis of GABA-AT inactivators, and a summary of CPP-115's pharmacological properties, including its superior visual safety profile and potency compared to vigabatrin.
unknown title 2011
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By the end of the third quarter of 2010, most of the safety studies described above, including results from assessments of the comparative retinotoxicity of CPP-115 versus vigabatrin, are expected to be completed.
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The visual safety of CPP-115 will be evaluated and compared to the only FDA approved GABA aminotransferase inhibitor drug, vigabatrin.
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Keppra or levetiracetam, H. Lundbeck's Sabril or vigabatrin, Pfizer's Neurontin or gabapentin and Lyrica or pregabalin, GlaxoSmithKline's Lamictal or lamotrigine, Novartis 'Trileptal or oxcarbazepine and Eisai's Zonegran or zonisamide.
Toronto Sun 2010
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The increased potency could enable the development of superior or alternative dosage forms and routes of administration compared with the marketed version of vigabatrin, Sabril® (which is marketed in the U.S. by Lundbeck Inc. for infantile spasms and refractory complex partial seizures).
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Phase II trial evaluating CPP-109, Catalyst's form of vigabatrin, to treat cocaine addiction.
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Phase II (b) clinical trial evaluating CPP-109, Catalyst's formulation of vigabatrin, for the treatment of cocaine addiction.
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