Definitions
from The Century Dictionary.
- noun A substance from which an enzym may be formed by internal change. Also
zymogene .
from the GNU version of the Collaborative International Dictionary of English.
- noun (Physiol. Chem.) A mother substance, or antecedent, of an enzyme or chemical ferment; -- applied to such substances as, not being themselves actual ferments, may by internal changes give rise to a ferment.
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun biochemistry A
proenzyme , orenzyme precursor , which requires a biochemical change (i.e. hydrolysis) to become an active form of the enzyme.
from WordNet 3.0 Copyright 2006 by Princeton University. All rights reserved.
- noun any of a group of compounds that are inactive precursors of enzymes and require some change (such as the hydrolysis of a fragment that masks an active enzyme) to become active
Etymologies
Sorry, no etymologies found.
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Examples
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Trypsin itself then cleaves lysine peptide bonds, and so, once a small amount of trypsin is generated, it participates in cleavage of its own zymogen, generating – more trypsin!
Vacuity of ID: Comments on Irreducible Complexity - The Panda's Thumb 2006
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Redman, David Sabatini and Yutaka Tashiro; it led to the characterization of the zymogen granules and to the discovery of the segregation of secretory products in the cisternal space of the endoplasmic reticulum.
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It may very likely produce the same change in the membrane that is caused by the entrance of the spermatozoon under normal circumstances -- membrane formation may be necessarily coincident with the liberation in the egg of some zymose which arises from a pre-existent zymogen.
Science and Morals and Other Essays Bertram Coghill Alan Windle 1893
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Protein C is a serine protease blood coagulation factor that circulates as an inactive zymogen and is activated by thrombin during blood coagulation to form activated protein C APC.
unknown title 2011
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Vande Haar penned a 12-verse epic in which he manages to rhyme words like "phospholipids," "hemorrhage" and "zymogen."
PhysOrg.com - latest science and technology news stories 2010
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As of this typing, it contains 13 scrolling screens of active netlabels (OK, I'm on a netbook; your scrolling may vary), from the Guadalajara, México-based zymogen.net (plus a bunch whose monikers start with numbers or symbols).
Boing Boing Marc Weidenbaum 2010
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This prodomain maintained MMP-2 as a zymogen and this loop is cleaved by MMP-14 after MMP-2 secretion given active form.
PLoS ONE Alerts: New Articles Virginie Renaud et al. 2010
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In such a model, cells secrete MMP-2 as an inactive zymogen (Pro-MMP-2) containing 8 disulphide bonds
PLoS ONE Alerts: New Articles Virginie Renaud et al. 2010
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This enzyme contains an amino-terminal signal sequence (Pre) that directs it to the secretory pathway via the endoplasmic reticulum (ER) and a propeptide (Pro) that maintains it as inactive zymogen
PLoS ONE Alerts: New Articles Virginie Renaud et al. 2010
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The loss of vacuole acidification in V-ATPase mutants prevents zymogen activation and causes defects in the proteolytic function of the vacuole
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