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Examples
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A drug called aprepitant can dramatically reduce nausea and vomiting in bone marrow transplants, a study has found.
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Global sales of EMEND aprepitant, a treatment for chemotherapy-induced nausea and vomiting, were $110 million for the fourth quarter, an increase of 23 percent compared with the same quarter of 2009, and $378 million for full year 2010, an increase of 19 percent compared with the same period last year.
unknown title 2011
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However, there previously had been only a few small studies on the benefit of aprepitant in bone marrow transplant patients, who receive higher doses of chemotherapy than most other cancer patients.
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The aprepitant group did not experience significantly more side effects than the placebo group.
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But a Loyola University Health System study has found the drug aprepitant can dramatically reduce both nausea and vomiting when combined with other anti-nausea drugs.
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Forty-nine percent of aprepitant patients experienced no vomiting and little or no nausea, compared with 15 percent of the placebo group.
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In Stiff's Phase III, blinded, prospective study, 90 bone marrow transplant patients were randomly assigned to receive aprepitant and 89 patients were randomly assigned to receive a placebo.
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Seventy-three percent of patients receiving aprepitant experienced no vomiting during the study period, compared with 23 percent of patients who received a placebo.
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During the fourth quarter Emend® (aprepitant) was approved in Japan.
THE MEDICAL NEWS Editors 2010
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"We did not know how effective aprepitant would be for bone marrow transplant patients," Stiff said.
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