Definitions
from The American Heritage® Dictionary of the English Language, 5th Edition.
- noun A large structural protein found in small amounts in the plasma membranes of muscle fibers. The absence of dystrophin due to a genetic mutation causes Duchenne's muscular dystrophy; insufficient dystrophin causes Becker muscular dystrophy.
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun biochemistry A
cytoplasmic structural protein that is deficient in some forms ofmuscular dystrophy
Etymologies
from The American Heritage® Dictionary of the English Language, 4th Edition
from Wiktionary, Creative Commons Attribution/Share-Alike License
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Examples
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•It is caused by an absence of a protein called dystrophin, which helps to keep the cells found in muscles intact.
Berks county news 2010
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In muscular dystrophy, the loss of a protein called dystrophin causes the muscle to literally tear itself apart, a process that cannot be repaired without cell-based intervention.
PhysOrg.com - latest science and technology news stories 2009
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This study is a Phase 2b, multicenter, randomized, double-blind, placebo-controlled, dose-ranging, efficacy and safety study, designed to document the clinical benefit of PTC124 when administered as therapy of patients with DMD/BMD due to a nonsense mutation (premature stop codon) in the dystrophin gene.
Neuromuscular Disorder Research Studies, Clinical Trials 2010
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The large gene for, say, dystrophin, the muscle-tissue protein that is linked to muscular dystrophy, contains about two million base pairs, or letters, of DNA.
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Duchenne Muscular Dystrophy is characterized by a loss of the protein dystrophin, leading to progressive muscle weakness and wasting through a complex cascade that involves impaired calcium homeostasis, mitochondrial dysfunction and oxidative stress.
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Torrente Y, Belicchi M, Sampaolesi M, Pisati F, Meregalli M, et al. (2004) Human circulating AC133 (+) stem cells restore dystrophin expression and ameliorate function in dystrophic skeletal muscle.
PLoS ONE Alerts: New Articles Ara Parlakian et al. 2010
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Professor Tremblay's team partnered with Cellectis, a French firm specializing in genome engineering, in order to design enzymes-called meganucleases-with the ability to correct the dystrophin gene.
Medindia Health News 2010
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Professor Tremblay's team partnered with Cellectis, a French firm specializing in genome engineering, in order to design enzymes-called meganucleases-with the ability to correct the dystrophin gene.
Medindia Health News 2010
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The effect of PRO044 will be assessed at the RNA level, to demonstrate specific exon 44 skipping, and at the protein level, to demonstrate novel dystrophin expression in muscle biopsies.
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The effect of PRO044 will be assessed at the RNA level, to demonstrate specific exon 44 skipping, and at the protein level, to demonstrate novel dystrophin expression in muscle biopsies.
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