Definitions
from the GNU version of the Collaborative International Dictionary of English.
- adjective (Genetics) of, pertaining to, or causing a type of mutation consisting of the insertion or deletion of one or more nucleotides in the nucleic acid structure of a gene, when the number of base pairs inserted or deleted is not a multiple of three. If the addition or deletion occurs in multiples of three, the unaffected nucleotides in the genome remain in the proper order ("frame") to be correctly translated into protein; in such cases of insertions or deletions not causing a frame shift, a functional though altered protein may be produced by the organism.
Frameshift mutations cause more profound changes in the composition of the protein resulting from translation of the mutated gene.
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun
frameshift mutation
Etymologies
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Examples
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I think you'll find the e-coli changed via a frameshift.
Blast From the Past 2010
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I think you'll find the e-coli changed via a frameshift.
Blast From the Past 2010
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Nylonase was a frameshift, much antibiotic and viral drug resistance is due to gene cassettes, transplanted finches develop new beak types in 20 years, multiple instances of plant speciation (same species) in the Pacific NW in the past 60 years …
19th Century Evangelical Scholars, Old Earth and Evolution 2010
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GU anomalies syndrome: These individuals usually carry changes known as nonsense or frameshift mutations that affect one working copy of the WT1 gene.
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There are also some examples of genes that can be turned on / off via regulated frameshift mutations.
Now this is how to critique Ken Ham's creation “museum” - The Panda's Thumb 2007
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He certainly knows next to nothing about biology he argued that frameshift mutations require 2 mutations… right next to one another.
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Did that last post undergo a frameshift mutation, or what?
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Ugt5b5 gene has four nonsense mutations and two frameshift mutations and appears to be a pseudogene.
PLoS ONE Alerts: New Articles Haiyan Huang et al. 2010
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Our friend sitting by the theatre at 8: 45 could've avoided distress at this sudden frameshift by rejecting the human tendency to turn 'blocks of time' into abstractions and invest them with qualities.
Wax Banks 2010
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Our friend sitting by the theatre at 8: 45 could've avoided distress at this sudden frameshift by rejecting the human tendency to turn 'blocks of time' into abstractions and invest them with qualities.
Wax Banks 2010
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