Definitions
from the GNU version of the Collaborative International Dictionary of English.
- noun (Biochem.) an enzyme catalyzing the transfer of a phosphate residue from ATP to a hexose, as in the formation of glucose-6-phosphate from glucose.
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun biochemistry Any
enzyme that catalyses thephosphorylation of ahexose
Etymologies
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Examples
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In the search for answers to these questions, suspicion fell most strongly on a reaction catalyzed by an enzyme called hexokinase (hek'soh-ky'nays).
The Human Brain Asimov, Isaac 1963
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It reduced levels of glycolytic enzymes such as hexokinase, phosphoglucoisomerase and aldolase levels, which are increased in hepatoma-bearing rats, and increased levels of gluconeogenic enzymes such as glucose. 6-phosphatase and fructose-I
Find Me A Cure 2009
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Early on, Meyerhof's group spent considerable effort to investigate the effects of hexokinase, which Meyerhof had discovered in 1927.
Otto Meyerhof and the Physiology Institute: the Birth of Modern Biochemistry 2010
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ANTIDIABETES Improving the secretion of insulin by repairing damaged pancreatic beta-cells; promoting the absorption of glucose in the liver; inhibiting the release of glucose from the liver by increasing hexokinase activity; reducing glucose-6-phosphatase activity
Forever Young M.D. Nicholas Perricone 2010
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Glucose transport is rapid so that the first irreversible step, hexokinase, must determine the rate of net flux.
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Thus any condition that affects the rate of glucose utilization of red cells must do so by either having an effect on G6P or on the activity of the hexokinase itself.
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A problem that warrants further study derives from our observation in 1967 that instead of being in the cytosol most of the hexokinase of tumor and animal cells is associated with the outer membrane of the mitochondrial fraction26.
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Subsequently, our lab used the pulse/chase method to study hexokinase in the steady state by comparing the 14C-G6P formed in an acid quench with that formed in a high substrate chase with time of quenching,
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We did pulse/chase experiments in which the labeled glucose came from hexokinase in the crystalline state either alone or together with ADP31.
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It has recently been reported that the release of mitochondrial hexokinase and some associated proteins may play a role in the onset of the apoptosis cascade27.
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