Definitions

from The American Heritage® Dictionary of the English Language, 5th Edition.

  • noun Any of a group of enzymes that catalyze the formation of double bonds by removing chemical groups from a substrate without hydrolysis or catalyze the addition of chemical groups to double bonds.

from Wiktionary, Creative Commons Attribution/Share-Alike License.

  • noun biochemistry Any of many classes of enzyme that catalyze the breaking of a specific form of bond

Etymologies

from The American Heritage® Dictionary of the English Language, 4th Edition

[Greek lūein, to loosen; see leu- in Indo-European roots + –ase.]

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Examples

  • Garcinia Cambogia: is a natural form of Hydroxcitric acid (HCA) which can inhibit an enzyme in cells, citrate lyase, which is needed for the conversion of carbohydrates into fat.

    Wil's Ebay E-Store amp;34; 2010

  • HCA has been thought to suppress enzymatic activity of citrate lyase which is responsible for lipogenesis and fatty acid biosynthesis.

    Scientific Blogging 2008

  • Previously reported Phase 2a results of LX2931, an inhibitor of sphingosine-1-phosphate lyase, demonstrated a favorable safety profile at all doses tested and suggested that rheumatoid arthritis patients treated with 150 mg of LX2931 once daily showed improvement in the primary efficacy endpoint of the study, the percentage of patients achieving an American College of Rheumatology 20 ACR20 response at week 12.

    unknown title 2011

  • Pereira JP, Matloubian M, Xu Y, Huang Y, et al. (2005) Lymphocyte sequestration through S1P lyase inhibition and disruption of S1P gradients.

    PLoS ONE Alerts: New Articles João Pedro Pereira et al. 2010

  • It promotes fat oxidation inhibiting ATP-citrate lyase and lowers the levels of leptin in obese subjects.

    Wil's Ebay E-Store amp;34; 2010

  • It promotes fat oxidation inhibiting ATP-citrate lyase and lowers the levels of leptin in obese subjects.

    Wil's Ebay E-Store amp;34; 2010

  • Moreover, Bio Shape works metabolically through Garcinia Cambogia, which inhibits an enzyme called citrate lyase to prevent excess fat.

    Wil's Ebay E-Store amp;34; 2010

  • We show by using cell extracts that Ku is essential for the efficient removal of AP sites near double-strand breaks and, consistent with this result, that joining of such breaks is specifically decreased in cells complemented with a lyase-attenuated Ku mutant.

    Naturejobs - All Jobs Steven A. Roberts 2010

  • Other product candidates include PEG-PAL (PEGylated recombinant phenylalanine ammonia lyase), which is currently in Phase II clinical development for the treatment of PKU; GALNS

    Medindia Health News 2010

  • It promotes fat oxidation inhibiting ATP-citrate lyase and lowers the levels of leptin in obese subjects.

    Wil's Ebay E-Store amp;34; 2010

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