Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun biology The
cellular development process that leads toplatelet production.
Etymologies
from Wiktionary, Creative Commons Attribution/Share-Alike License
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Examples
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SHIP may play an important role in regulation of essential signaling pathways that control early megakaryocytopoiesis
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We hypothesize that SHIP might control megakaryocytopoiesis through effects on proliferation of megakaryocyte progenitors (MKP) and megakaryocytes (MK).
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SHIP deficient mice have been shown to have increased levels of IL-6 [5] and TPO (Kerr et al, unpublished results) that could contribute to enhance megakaryocytopoiesis in these mice.
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Based on the defined role for SHIP in signaling pathways for cytokine / chemokines that also regulate MK and platelet biology, we hypothesized that SHIP might be involved in the regulation of megakaryocytopoiesis and platelet production in vivo.
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SHIP deficient mice have been shown to have increased levels of IL-6 [5] and TPO (Kerr et al, unpublished results) that could contribute to enhance megakaryocytopoiesis in these mice.
PLoS ONE Alerts: New Articles Lia E. Perez et al. 2008
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Circulating platelets sequester free TPO, and thereby limit megakaryocytopoiesis during steady-state hematopoiesis
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SHIP may play an important role in regulation of essential signaling pathways that control early megakaryocytopoiesis
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3 Department of Chemistry, The Scripps Research Institute, San Diego, California, United States of America The SH2-containing-5′inositol phosphatase-1 (SHIP) influences signals downstream of cytokine / chemokine receptors that play a role in megakaryocytopoiesis, including thrombopoietin, stromal-cell-derived-Factor-1 / CXCL-12 and interleukin-3.
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3 Department of Chemistry, The Scripps Research Institute, San Diego, California, United States of America The SH2-containing-5′inositol phosphatase-1 (SHIP) influences signals downstream of cytokine / chemokine receptors that play a role in megakaryocytopoiesis, including thrombopoietin, stromal-cell-derived-Factor-1 / CXCL-12 and interleukin-3.
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