Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun medicine A
human monoclonal antibody used in the treatment of somecancers
Etymologies
from Wiktionary, Creative Commons Attribution/Share-Alike License
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Examples
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S&P Equity Research analyst Frank DiLorenzo noted that the response rate for panitumumab arm was 8% versus a response rate of 10.8% for Erbitux, a cancer drug marketed by ImClone Systems and Bristol-Myers Squibb.
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"Clinical data suggests that panitumumab is as effective as Erbitux, but its milder safety profile and more convenient dosing could make it a preferred choice among oncologists," noted Anderson.
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The U.S. Food and Drug Administration granted priority review status to Amgen's colon cancer drug, panitumumab, the company announced after Monday's closing bell.
Eye On Stocks For Tuesday, June 13Eye On Stocks For Tuesday, June 13, 2006 2006
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Amgen said this morning Phase III trial data showed that panitumumab "significantly improved" survival rates in colon cancer patients who previously failed chemotherapy.
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Sales of Erbitux, a cancer drug licensed from ImClone Systems, could rise as it is expanded into other indications, but growth could be held in check by Amgen's panitumumab.
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"The delay of PACCE data for panitumumab until late 2006 removes the only major near-term pipeline catalyst for Amgen," the firm noted.
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The pending merger will allow Amgen to reap all the profits from promising cancer-drug panitumumab, currently in late-stage trials.
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"We are not convinced the FDA will grant priority review due the lack of an unmet medical need in refractory mCRC with the availability of Erbitux and the seemingly comparable efficacy of panitumumab," wrote analyst David Molowa.
Eye On Stocks For Tuesday, June 13Eye On Stocks For Tuesday, June 13, 2006 2006
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"At this point, we expect Erbitux to maintain its share in combination with chemo to treat colorectal cancer and think panitumumab could take some share in the monotherapy area only."
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Typically, patients who fail 5-FU, oxaliplatin, irinotecan, and bevacizumab-containing therapies, and who have wild-type KRAS status receive EGFR monoclonal antibody therapy with either cetuximab or panitumumab.
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