polyposis

Because Familial adenomatous polyposis is hereditary, the risk of developing the features associated with FAP can be passed from generation to generation in a family.

Familial Adenomatous Polyposis 2009

Individuals with familial adenomatous polyposis are also at increased risk to develop benign and malignant tumors outside of the gastrointestinal tract.

Familial Adenomatous Polyposis 2009

It is important to note that patients with familial adenomatous polyposis are at increased risk to develop other types of cancer in addition to cancer of the colon or stomach.

Familial Adenomatous Polyposis 2009

Approximately 75 percentto 80 percentof patients with familial adenomatous polyposis inherit an altered copy of the APC gene from a parent who also has FAP.

Familial Adenomatous Polyposis 2009

It is caused by alterations in the adenomatous polyposis coli (APC) gene.

Familial Adenomatous Polyposis 2009

If a mutationin either BMPR1A or SMAD4 is identified, the genetic counselor can next examine whether the alteration has been previously reported in other individuals with juvenile polyposis syndrome (JPS).

Juvenile Polyposis 2009

How is juvenile polyposis syndrome (JPS) inherited?

Juvenile Polyposis 2009

Additional sources of information for familial adenomatous polyposis (FAP)

Familial Adenomatous Polyposis 2009

In patients with juvenile polyposis syndrome, however, each cell contains only one working copy of either BMPR1A or SMAD4.

Juvenile Polyposis 2009

Colorectal cancer is the most common cancer seen in individuals with juvenile polyposis syndrome (JPS), but cancers in other parts of the digestive system have also been described, such as cancers of the stomach, upper gastrointestinal tract and pancreas.

Juvenile Polyposis 2009