proteostasis

This biological machinery controlling the folding and function environment of the cell is referred to as the proteostasis network and is central for life.

PhysOrg.com - latest science and technology news stories 2009

This biological machinery controlling the folding and function environment of the cell is referred to as the proteostasis network and is central for life.

innovations-report 2009

This feature is reminiscent of its potential mechanism of action, Balch said, perhaps involving chromatin remodeling leading to an altered, protective proteostasis environment in the lung cell that could be sustainable.

PhysOrg.com - latest science and technology news stories 2009

This feature is reminiscent of its potential mechanism of action, Balch said, perhaps involving chromatin remodeling leading to an altered, protective proteostasis environment in the lung cell that could be sustainable.

innovations-report 2009

Based on earlier studies of the folding environment required for CFTR function published in the journal Cell, the scientists reasoned that altering HDAC function might also rebalance proteostasis networks in the cell to favor functional restoration.

PhysOrg.com - latest science and technology news stories 2009

Rather than attempting to directly target or replace the mutant CFTR proteins present in cystic fibrosis patients-an approach that had so far failed to yield dramatic new treatments for the DF508 disease-Balch and colleagues sought instead to adjust the cell folding or maintenance proteostasis machinery of the cell to make a new cellular environment that would

PhysOrg.com - latest science and technology news stories 2009

"By rebalancing the proteostasis program to provide a more supportive cellular environment," said Balch, "the cells appear to treat the mutation more like a polymorphism [genetic differences that are responsible for individual diversity] rather than something dangerous needing to be completely eliminated."

innovations-report 2009

Using a bioinformatics approach led by the Gerard Manning laboratory at the Salk Institute of Biological Sciences, the team showed that the compound increased the functioning of mutated CFTR proteins at multiple levels in the proteostasis network.

innovations-report 2009

Based on earlier studies of the folding environment required for CFTR function published in the journal Cell, the scientists reasoned that altering HDAC function might also rebalance proteostasis networks in the cell to favor functional restoration.

innovations-report 2009

Using a bioinformatics approach led by the Gerard Manning laboratory at the Salk Institute of Biological Sciences, the team showed that the compound increased the functioning of mutated CFTR proteins at multiple levels in the proteostasis network.

PhysOrg.com - latest science and technology news stories 2009