syncytiotrophoblast

The trophoblast is made up of an internal layer of cubical or prismatic cells, the cytotrophoblast or layer of Langhans, and an external layer of richly nucleated protoplasm devoid of cell boundaries, the syncytiotrophoblast.

I. Embryology. 11. Development of the Fetal Membranes and Placenta 1918

The cells of the trophoblast become differentiated into two strata: an outer, termed the syncytium or syncytiotrophoblast, so named because it consists of a layer of protoplasm studded with nuclei, but showing no evidence of subdivision into cells; and an inner layer, the cytotrophoblast or layer of Langhans, in which the cell outlines are defined.

I. Embryology. 5. Segmentation of the Fertilized Ovum 1918

The endothelial lining of the uterine vessels ceases at the point where they terminate in the intervillous space which is lined by the syncytiotrophoblast.

I. Embryology. 11. Development of the Fetal Membranes and Placenta 1918

The vessels of the villus are surrounded by a thin layer of mesoderm consisting of gelatinous connective tissue, which is covered by two strata of ectodermal cells derived from the trophoblast: the deeper stratum, next the mesodermic tissue, represents the cytotrophoblast or layer of Langhans; the superficial, in contact with the maternal blood, the syncytiotrophoblast (Figs. 36 and 37).

I. Embryology. 11. Development of the Fetal Membranes and Placenta 1918

It has been demonstrated that isolated cytotrophoblasts from preeclampsia or fetal growth restriction and their derived syncytiotrophoblast are more sensitive to apoptosis compared with those from normal pregnancies

PLoS ONE Alerts: New Articles Tai-Ho Hung et al. 2010

Such a change in the prevailing oxygen concentration may lead to a difference in the susceptibility of cytotrophoblasts and syncytiotrophoblast for women with preeclampsia in comparison to those who have healthy pregnancies

PLoS ONE Alerts: New Articles Tai-Ho Hung et al. 2010

In addition to allowing regeneration of syncytiotrophoblast and investigating chronic regulation of apoptosis and autophagy, another reason for us to incubate villous explants and cytotrophoblastic cells under normoxia or HR for 48 hours before administration of vitamins C and E is to precondition the trophoblast cells with our experimental settings.

PLoS ONE Alerts: New Articles Tai-Ho Hung et al. 2010

Sibley CP, Jones CJ, Turner MA, Greenwood SL (2001) The functional regeneration of syncytiotrophoblast in cultured explants of term placenta.

PLoS ONE Alerts: New Articles Tai-Ho Hung et al. 2010

Indeed, degeneration of the syncytiotrophoblast is noted in third-trimester explants after 8 hours of culture; however, a newly formed trophoblast layer is found by 48 hours

PLoS ONE Alerts: New Articles Tai-Ho Hung et al. 2010

Digital images from ten randomly selected fields that provided a minimum of 500 nuclei within the trophoblast layer (syncytiotrophoblast and cytotrophoblasts) for each section were saved.

PLoS ONE Alerts: New Articles Tai-Ho Hung et al. 2010