Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- adjective genetics Describing a
chromosome orientation in which both sisterkinetochores are attached to the samespindle
Etymologies
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Examples
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Mailhes JB, Mastromatteo C, Fuseler JW (2004) Transient exposure to the Eg5 kinesin inhibitor monastrol leads to syntelic orientation of chromosomes and aneuploidy in mouse oocytes.
PLoS ONE Alerts: New Articles Vincent Gache et al. 2010
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Like merotelic attachments, syntelic attachments are corrected by the same Aurora B dependent pathway
PLoS ONE Alerts: New Articles Alexander Samoshkin et al. 2009
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For the cell population analysis, both condensin depletion and Aurora B inhibition showed a similar (90%) proportion of abnormal (unrecovered) metaphases with ample signs of syntelic and merotelic attachments still persisting as late as 40 min after the release from monastrol.
PLoS ONE Alerts: New Articles Alexander Samoshkin et al. 2009
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The persistence of unrecovered syntelic attachments also indicate that there is apparently a constitutive defect of Aurora B activity at centromeres upon condensin depletion, in addition to the tension-specific defect
PLoS ONE Alerts: New Articles Alexander Samoshkin et al. 2009
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The results described here indicate that dysfunction of human condensin both compromises an important controlling mechanism (correction of syntelic and merotelic attachments) and leads to chromosome damage (breaks) and nondisjunction.
PLoS ONE Alerts: New Articles Alexander Samoshkin et al. 2009
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The magnified region shows syntelic mis-attachment of individual chromosomes.
PLoS ONE Alerts: New Articles Alexander Samoshkin et al. 2009
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Monastrol arrest produces syntelic chromosomes in SMC2-depleted cells.
PLoS ONE Alerts: New Articles Alexander Samoshkin et al. 2009
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Aurora B activity in correcting syntelic and merotelic attachments
PLoS ONE Alerts: New Articles Alexander Samoshkin et al. 2009
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Kinetochore defects in condensin-depleted cells lead to a high incidence of syntelic and merotelic mis-attachments of kinetochore microtubules, which are not corrected prior to anaphase onset.
PLoS ONE Alerts: New Articles Alexander Samoshkin et al. 2009
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The EM images (Fig. 5) collectively reinforce the correlation between stretching of centromeric chromatin, spreading of microtubule-binding modules of individual kinetochores and a net increase in uncorrected syntelic, merotelic, and double-merotelic attachments in condensin-depleted cells.
PLoS ONE Alerts: New Articles Alexander Samoshkin et al. 2009
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