Definitions
from The American Heritage® Dictionary of the English Language, 5th Edition.
- noun A malignant teratoma occurring most commonly in the testis.
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun a
malignant tumor , most often found in thetestes
Etymologies
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Examples
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[12] Mintz B, Illmensee K. Normal genetically mosaic mice produced from malignant teratocarcinoma cells.
The 2007 Nobel Prize in Physiology or Medicine - Advanced Information 2007
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Robertson, E. Formation of germ-line chimaeras from embryo-derived teratocarcinoma cell lines.
The 2007 Nobel Prize in Physiology or Medicine - Advanced Information 2007
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Isolation of a pluripotent cell line from ealry mouse embryos cultured in medium conditioned by teratocarcinoma stem cells.
The 2007 Nobel Prize in Physiology or Medicine - Advanced Information 2007
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[9] Martin GR, Evans, M.J. Differentiation of clonal lines of teratocarcinoma cells: formation of embryoid bodies in vitro.
The 2007 Nobel Prize in Physiology or Medicine - Advanced Information 2007
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Evans, M.J. The fate of teratocarcinoma cells injected into early mouse embryos.
The 2007 Nobel Prize in Physiology or Medicine - Advanced Information 2007
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[8] Martin GR, Evans, M.J. The morphology and growth of a pluripotent teratocarcinoma cell line and its derivatives in tissue culture.
The 2007 Nobel Prize in Physiology or Medicine - Advanced Information 2007
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Sato, G.H. In vitro growth and differentiation of clonal populations of multipotential mouse cells derived from a transplantable testicular teratocarcinoma.
The 2007 Nobel Prize in Physiology or Medicine - Advanced Information 2007
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Beginning in 1972 they exposed teratocarcinoma cells to a very strong chemical agent that caused mutations, and then injected the mutated cancer cells into mice to see if there was a genetic pattern to the weird variations that grew out of the tumor; as a control they injected other mice with unmutated teratocarcinoma cells.
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They knew that such an approach could theoretically work, because in 1989, working with a mouse tumor different from teratocarcinoma, Boon's group identified a tumor-specific antigen that they called P1A in mice.
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Still working with teratocarcinoma, he once again stumbled onto a remarkable aspect of the immune response to cancer.
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