Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun biochemistry A filament-associated
protein that binds tokeratin fibres inepithelial cells
from WordNet 3.0 Copyright 2006 by Princeton University. All rights reserved.
- noun the main protein of the keratohyalin granules
Etymologies
Sorry, no etymologies found.
Support
Help support Wordnik (and make this page ad-free) by adopting the word filaggrin.
Examples
-
Later on, an approved gene name filaggrin-2 (gene symbol FLG2) was suggested by the HUGO / GDB Nomenclature Committee.
PLoS ONE Alerts: New Articles Zhihong Wu et al. 2009
-
By using these tandem repeats as queries in BLAST homolog searches against the human protein database, the most positive hit homologous to each A-type repeat was from repetitive domains of hornerin (50-77\% identity) whereas that homologous to each B-type repeat was from filaggrin units (28-39\% identity) (data not shown).
PLoS ONE Alerts: New Articles Zhihong Wu et al. 2009
-
As a vital component of healthy skin, filaggrin is also a precursor of natural moisturizing factors.
PLoS ONE Alerts: New Articles Zhihong Wu et al. 2009
-
Substrate specificity and structural relationships of the natural substrates trichohyalin and filaggrin.
PLoS ONE Alerts: New Articles Zhihong Wu et al. 2009
-
McKinley-Grant LJ, Idler WW, Bernstein IA, Parry DA, Cannizzaro L, et al. (1989) Characterization of a cDNA clone encoding human filaggrin and localization of the gene to chromosome region 1q21.
PLoS ONE Alerts: New Articles Zhihong Wu et al. 2009
-
The liberated filaggrin is an essential component of the SC that participates in the aggregation of keratin filaments into bundles and promote the flattened shape of dead-cell remnants
PLoS ONE Alerts: New Articles Zhihong Wu et al. 2009
-
We provide evidences that like filaggrin, FLG2 is initially expressed by upper granular cells, proteolytically processed and deposited in the stratum granulosum and stratum corneum (SC) layers of normal epidermis.
PLoS ONE Alerts: New Articles Zhihong Wu et al. 2009
-
Recent genetic studies have shown that mutations within the gene encoding the SFTP filaggrin cause ichthyosis vulgaris and are major predisposing factors for atopic dermatitis.
PLoS ONE Alerts: New Articles Zhihong Wu et al. 2009
-
Palmer CNA, Irvine AD, Terron-Kwiatkowski A, Zhao Y, Liao H, et al. (2006) Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis.
PLoS ONE Alerts: New Articles Zhihong Wu et al. 2009
-
FLG gene causing ichthyosis vulgaris, filaggrin units represent major risk factors for atopic dermatitis (AD) and secondary allergic diseases
PLoS ONE Alerts: New Articles Zhihong Wu et al. 2009
qroqqa commented on the word filaggrin
In 2006, a mutation in the gene for the protein filaggrin – which keeps foreign substances out of the skin – was shown to increase the risk of eczema.
—New Scientist, 28 June 2008
July 14, 2008