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Examples
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These are calcium channels that are on nerves that conduct pain signals, and it's a validated central nervous system target in that there is an existing medication called Prialt ziconotide, which is only available for direct injection into the brain, that blocks these receptors.
Zalicus Poised for Reversal With Pending Catalyst -- Seeking Alpha 2010
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Animal species too are treasure troves of medicines: the cone snail yields a toxin (recently FDA-approved under the name "Prialt") that is a thousand times more potent than morphine as a painkiller but does not lead to tolerance or addiction.
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Animal species too are treasure troves of medicines: the cone snail yields a toxin (recently FDA-approved under the name "Prialt") that is a thousand times more potent than morphine as a painkiller but does not lead to tolerance or addiction.
Newspaper Tree 2009
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Animal species too are treasure troves of medicines: the cone snail yields a toxin (recently FDA-approved under the name "Prialt") that is a thousand times more potent than morphine as a painkiller but does not lead to tolerance or addiction.
Newspaper Tree 2009
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The drug Prialt derived from this cone snail is effectively treating pain, including phantom-limb pain; it's non addictive and the human body does not appear to develop a tolerance.
Dr. Reese Halter: Mother Nature's Medicine Cabinet Dr. Reese Halter 2010
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The shareholders have also accused management of mismanaging the marketing of pain drug Prialt before selling it for an undisclosed sum to Azur Pharma Ltd., a privately held company managed by a former Elan executive.
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Mr. Sonderby also accused Elan of mismanaging the marketing of pain drug Prialt "for years," before selling it for an undisclosed sum to a privately held Irish company called Azur Pharma, which is managed by a former Elan executive.
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The drug Prialt derived from this cone snail is effectively treating pain, including phantom-limb pain; it's non addictive and the human body does not appear to develop a tolerance.
Dr. Reese Halter: Mother Nature's Medicine Cabinet Dr. Reese Halter 2010
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It developed Prialt (ziconotide), a non-opioid pain killer that blocks N-type calcium channels.
Archive 2007-04-01 2007
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In 2000, just when he was ready to give up on finding relief, Pearson's doctor told him about a clinical trial for a new drug called ziconotide (brand name: Prialt).
PHARMACY ISLAND 2007
vendingmachine commented on the word Prialt
"Prialt or ziconotide is a synthetic compound identical to a toxin in the venom of the Conus magus sea snail. This is remarkable in itself, because natural compounds are almost always chemically modified to make them work better as drugs. In this case, nature perfected the compound on its own.
Prialt is 1,000 times more powerful than morphine, but, unlike morphine, it is not believed to be addictive. The FDA approved its use for chronic, intractable pain such as that suffered by people with cancer, AIDS or certain neurological disorders. It is delivered directly into fluid surrounding the spinal cord by external or implanted pumps.
Prialt may be just the first of many new medicines derived from cone snail venom. There are about 500 different types of cone snails, and each one typically produces about 100 different toxins in its venom. Some instantly shock the snail's prey, as does the sting of an electric eel, scorpion or sea anemone. Others cause paralysis, like the venoms of cobras and Japanese puffer fish.
Scientists are testing the potential of dozens of cone snail toxin to treat epilepsy, cardiovascular disease and other disorders. Eventually, the molecules in sea snail venoms may help to treat Alzheimer's disease, Parkinson's disease, schizophrenia and depression.
*the toxin (which later was developed into Prialt) was discovered by a teenager named J. Michael McIntosh, just days after graduating from high school.
March 9, 2016
vendingmachine commented on the word Prialt
To find out more about the fascinating history of Prialt and its developers, read
here.
March 9, 2016