Definitions
from The American Heritage® Dictionary of the English Language, 5th Edition.
- noun A large bone marrow cell with a lobulate nucleus that gives rise to blood platelets.
from the GNU version of the Collaborative International Dictionary of English.
- noun (Anat.) A large bone marrow cell not usually found in the circulating blood; it is regarded as the precursors of blood platelets; it is up to 100 μm in diameter, with a polyploid nucleus. Also referred to as
megacaryocyte ,megalokaryocyte , andthromboblast .
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun anatomy A large
cell , found inbone marrow , responsible for the production ofplatelets .
from WordNet 3.0 Copyright 2006 by Princeton University. All rights reserved.
- noun a large bone marrow cell; regarded as the source of blood platelets
Etymologies
from Wiktionary, Creative Commons Attribution/Share-Alike License
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Examples
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The cytoplasm of the megakaryocyte fragments at the edge of the cell.
Archive 2008-02-01 James Killus 2008
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Platelets are formed in the cytoplasm of a very large cell, the megakaryocyte.
It's Always about the Blood James Killus 2008
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Platelets are formed in the cytoplasm of a very large cell, the megakaryocyte.
Archive 2008-02-01 James Killus 2008
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The cytoplasm of the megakaryocyte fragments at the edge of the cell.
It's Always about the Blood James Killus 2008
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"Our study indicates that the dysregulation of PLAU in Quebec platelet disorder extends beyond megakaryocyte lineage, to involve other cells of the myeloid lineage," the investigator said.
MedPageToday.com - medical news plus CME for physicians 2010
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The condition also is characterized by proteolysis of platelet α-proteins such as platelet factor V and von Willebrand factor, further interfering with clot function, and with increased uPA messenger RNA levels, particularly during megakaryocyte differentiation.
MedPageToday.com - medical news plus CME for physicians 2010
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"Our study indicates that the dysregulation of PLAU in Quebec platelet disorder extends beyond megakaryocyte lineage, to involve other cells of the myeloid lineage," the investigator said.
MedPageToday.com - medical news plus CME for physicians 2010
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The condition also is characterized by proteolysis of platelet α-proteins such as platelet factor V and von Willebrand factor, further interfering with clot function, and with increased uPA messenger RNA levels, particularly during megakaryocyte differentiation.
MedPageToday.com - medical news plus CME for physicians 2010
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Lagrue-Lak-Hal AH, Debili N, Kingbury G, Lecut C, Le Couedic JP, et al. (2001) Expression and function of the collagen receptor GPVI during megakaryocyte maturation.
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Boer AK, Los EL, Esselink MT, Vellenga E (2005) Stem cell factor synergistically enhances thrombopoietin-induced STAT5 signaling in megakaryocyte progenitors through JAK2 and Src kinase.
PLoS ONE Alerts: New Articles Lina Han et al. 2009
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